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Regenerative Healing Through Very Small Embryonic-Like Stem Cells (VSELs)
At Greenberg Regenerative Medicine, we push the frontier of regenerative medicine by harnessing the potential of VSEL therapy, a next-generation approach to repairing tissue, modulating immune function, and promoting systemic healing at the cellular level. VSELs are a class of ultra-small, pluripotent stem cells found endogenously in adults, which some researchers believe can be awakened or expanded to assist in repair and regeneration. Our goal is to safely apply VSEL technology to help patients with a wide range of chronic, degenerative, autoimmune, and neurological conditions.
Below, you’ll find an overview of VSEL therapy — what it is, how it works, and how Greenberg Regen is applying it — plus links to in-depth pages for each major topic.
What Is VSEL Therapy?
VSEL therapy involves the isolation, activation, and reintfusion (or local delivery) of Very Small Embryonic-Like stem cells to help the body stimulate repair, modulate the immune system, and potentially regenerate damaged tissues. Because VSELs are thought to exist endogenously, the approach aims to harness or boost the body’s innate regenerative capacity, rather than implanting large exogenous cell populations.
Key features of VSEL therapy include:
Autologous : we work with the patient’s own VSELs, limiting rejection and immunogenic risk.
Targeted delivery: depending on indication, VSELs may be delivered systematically (e.g. IV) or locally (e.g. into tissue or organ).
Adjunctive support: VSEL therapy is often combined with supportive measures — nutritional, metabolic, anti-inflammatory, or signaling modulators — to optimize the microenvironment for repair.
Regulation & oversight: We follow best practices in cell processing, sterility, potency validation, and clinical protocols to ensure safety and traceability.
Because VSEL-based medicine is still emerging, our approach is guided by evolving preclinical and early clinical evidence, and we emphasize rigorous monitoring, transparency, and patient education.
Conditions & Applications
VSEL therapy holds promise across a broad spectrum of indications. At Greenberg Regenerative Medicine, we currently focus on:
Neurological & autoimmune disorders
Cardiovascular and Metabolic Conditions
Peripheral and Respiratory Disorders
Ophthalmological Conditions
Post Infections and Trauma Related Conditions
Musculoskeletal and Structural Conditions
Reproductive Health
Dermatological and Hair Conditions
Pediatric Applications
Safety, Efficacy & Clinical Evidence
Because VSEL therapy is a frontier area, much of the evidence is preclinical or early phase. However, early studies and case reports suggest potential benefits in tissue repair, anti-inflammatory modulation, and stem cell niche support. On our VSEL Therapy Efficacy & Safety page, we provide a critical review of the literature, describe safety considerations, and outline how we monitor risks (e.g. overgrowth, immunologic response, unintended differentiation).
We are transparent about limitations, and we counsel patients thoroughly about realistic outcomes, time horizons, and the experimental nature of many protocols.
VSEL Therapy Pricing
At Greenberg Regenerative Medicine, we believe in full transparency when it comes to the cost of advanced regenerative treatments like VSEL therapy. Because each patient’s protocol is personalized based on their condition, dosage, and number of sessions, pricing can vary — but we provide a clear estimate during your consultation before any treatment begins.
While VSEL therapy is not currently covered by most insurance plans, we offer several flexible financing options through trusted partners such as PatientFi and CareCredit, allowing patients to spread the cost of care into manageable monthly payments. Our team will walk you through all available options and help you find a plan that fits your budget so you can focus on healing, not finances.
Ready to See what VSEL Therapy Can Do For You?
Click below to book your appointment and explore VSEL and other Regenerative Therapies with Dr. Greenberg. Our office is conveniently located just outside of Philadelphia in Bryn Mawr, PA.